Introduction
Pipette-based workflows are fundamental to applications ranging from PCR diagnostics to single-cell genomics. However, contamination—whether via aerosol carryover or reagent adsorption—can compromise entire studies. Axiflow’s sintered porous filters, engineered from proprietary low-binding polymers, offer a first-line defense without sacrificing accuracy or ergonomic performance.
1. Aerosol-Barrier Architecture
The filter matrix utilizes a precise pore size range (0.5–2 µm) combined with high tortuosity. This configuration blocks over 99.9% of aerosols while allowing unrestricted airflow during aspiration, eliminating false positives in highly sensitive assays like qPCR and NGS library preparation.
2. Ultra-Low Binding Chemistry
Conventional polypropylene (PP) often binds nucleic acids and proteins. Axiflow’s surface-modified PP/PE blend exhibits <1 ng DNA loss per 100 µL (per ISO 18385) and preserves enzyme activity even after extended contact—crucial for ensuring diagnostic reproducibility.
3. Ergonomic Design & High-Throughput Compatibility
The filters add only 4–6 mg to the pipette tip mass and maintain a smooth inner wall profile, ensuring seamless compatibility with multichannel pipettes and automated liquid handling systems. Optional antistatic treatments enhance tip-pick performance on robotic carousels.
4. Cleanroom Manufacturing & Sterility Assurance
Manufactured in ISO Class 7 cleanroom environments, each tip undergoes 100% machine-vision inspection, followed by gamma or e-beam sterilization (SAL 10⁻⁶). Bioburden, endotoxin, and particulate testing comply with USP <85> and <788>, making filters immediately suitable for clinical applications.
5. Regulatory Compliance & Sustainability Focus
All raw materials comply with REACH, RoHS, and USP Class VI standards. Additionally, Axiflow offers a bio-based PP product line, reducing carbon footprint by up to 60% without compromising filter performance.
Conclusion
By integrating precision porosity, biocompatible chemistry, and stringent manufacturing standards, Axiflow delivers pipette tip filters that ensure data integrity in the world’s most demanding laboratories—while offering the flexibility to support custom solutions.